That's Flex channel. What'll happen is you'll be running all sticks at 2133, the cpu will use the 16Gb dual channel as primary and if that gets used up will chase with the 8Gb in single channel.
So unless you use something that's so ram heavy that it goes beyond 16Gb of usage, there's 0 benefit to having the extra 8Gb in a slower configuration and the drawback of additional strain on the memory controller.