You should be good in most games as others have said, max settings is not 100% necessary for 4k, the different texture levels in 4k doesn't make a huge difference unlike 1080p and 1440p does, you would still get a very clear picture, still better than those two.
Here's some pictures if you wanna compare, there only difference I see is the light and shadow and how far the clear details reach, that's about it really, you would still get that 4k clarity.
BF4 settings: Ultra:
http://i.imgur.com/8weImYx.jpg Low:
http://i.imgur.com/Nq8fR84.jpg
Crysis 3 settings: Ultra:
http://i.imgur.com/KWUETkm.jpg Low:
http://i.imgur.com/Nf1Oby6.jpg
I'm not sure if your GPU has mantle but it really helps if you do in games that supports mantle. Also, AA is useless at 4k, so never bother with it, it is not a requirement to make the picture look better like lower resolutions do.
Edit: Or actually you could just switch to a single 290x if you want that 4GB of VRAM and play on high to ultra for most games, I'm pretty sure it has mantle, the only game I have encountered that really needs CFX is Crysis 3, but since there's like almost nothing to do after you beat the game, it's not a big deal. For others like BF4, DA: Inquisition, FC4, you should be able to get up to high+ with that single 290x. You should most likely get a constant 60 fps at high or ultra in older games like Fable Anniversary, Skyrim, Mass Effect Trilogy, those sort of games. So I think this would be a better option for you, because actually that's what I'm running at the moment, only using 1/4 of my GPUs, mantle helps "a lot" with a single GPU in games that supports it. Just make sure you have a really good air flow in your case especially gaming at 4k.