By the way, there is a simple test. Download IntelliJ and watch in a live view how different font smoothing settings change the content or the sample text. It's really startling. I'm not even sure 8K will be enough to get rid of smoothing entirely.
Even comparing laser print to screen reveals substantial difference at how fonts look. Obviously, the smaller the print, the bigger the difference. Everything might seem perfectly sharp from two feet away but some letters (lines) seem thicker than others even if they shouldn't. For example, m can have three different stems and i can swell either to the left or to the right. Which, as I said previously, changes the intended distance between letters, which, in turn, needs to be compensated somehow by the brain (provided the original font has been truly optimized for readability).
That's why proofreaders and copy editors have (or had?) always tended to read a printed copy at least once.