which is the OS drive?
whichever isn't;
you should be able to open Disk Manager,
delete all partitions,
format the drive and have a freshly wiped & cleaned storage disk.
then unplug the SATA data cable from that storage drive
and run a fresh Windows install on the OS drive:
If you are looking for the Windows 11 Clean install tutorial, you can find that here: Windows 11 Clean install tutorial (Click here) Otherwise, welcome to the Windows 10 Clean install tutorial This tutorial is intended to help you, step by step, to perform a clean install of Windows...
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after Windows is installed
re-plug the SATA data cable to your storage drive and you should be good to go with a fresh OS installation
and a clean storage drive.
to wipe the storage drive and install a fresh Windows package on your OS drive
you will be deleting all of your current files,
removing all of your installed programs and drivers,
and removing any customization you have done within Windows.
you will be back at a default Windows state
where you will need to reinstall everything regarding any system\component drivers and any software you regularly use.