its always better to pair memory modules,than to run a single stick. You CAN run a single stick,which will run in single channel mode,but dual channel mode (with 2 sticks) has long been shown to have better performance and modern motherboards are more designed for it. Don't mix different sizes of RAM either,thats never a good thing,in case you the thought happened to run across you. I am sure you know not to,but just saying for good measure. As for your original question,as to whether or not you can run dual gfx with dual sticks or a single stick,I personally dont think it should matter. To be honest,I dont know for sure,as I dont have dual gfx and already have dual sticks of memory in a dual channel config.At first,I mistakenly set...