It depends on which card you have. How many outputs do you have and what are they. My card has 2x mini DP ports, 1x HDMI and 1x DVI and I can use all of them. Some cards will have a 5th output, another DVI port. If you have one of these, you can usually only use 2 out of the 3 of the HDMI/DVI ports and the remaining monitors must be on Display port.