Insufficient System on Chip voltage may be the cause as it is related to the stability of the integrated USB controller. After reflashing the BIOS and resetting to system defaults, disabling turbo, ceasing the use of all tweaking tools, uninstalling the USB drivers and deleting them and clean installing them, visiting the properties of every USB port and root hub in device manager and disabling allowing to shut off the device to save power, disabling USB selective suspend in the power plan, and confirming a full pass on Passmark MemTest, one might want to confirm there is nothing wrong with any of the attached devices by running them on another system or using a third-party USB to PCIe expansion card to isolate the issue to the board's USB controller. Once isolated this would be grounds for an RMA of the motherboard, as it does not function properly at default settings. Since the problem is not universal, some motherboards may have received insufficient validation testing. I don't own a dysfunctional system like this and can't experiment on the problem myself.