@mikewinddale In my testing it is even worse than sticking to 4 or 8 populated channels. Anything less than all 8 channels has a significant impact on performance. The hardware setup for these tests was: 3995wx, ASUS Pro Sage, 256GB 3200MHz, writing to 4 x Samsung 980 Pro in RAID-0. Interesting is that while throughput dropped, meaning that technically the system is doing less work, the CPU utilization increased when all 8 memory channels weren't populated. I do wonder if the different channel-to-chiplet affinity between your 16-core and my 64-core model is responsible for why you don't see as big of a hit as I do with only 4 channels populated.