So AMD's opportunities this year seem like 1) better mobile parts to take advantage of the shortages there (and maybe steal a little market share), 2) maybe muscling into the mid-to-high-end GPU market a bit more, and 3) semi-custom, though that's lower-margin.
The most plausible extreme possibilities seem to mostly depend on Intel. If Intel can't make 10nm server parts in large quantities or at high core counts, for example, maybe AMD sees good server growth. If things start clicking for Intel product-wise, and Intel chooses to cut prices a ton rather than continue to bet on their (amazing) inertia, that's harsher.
Longer term it seems like AMD CPUs stay competitive for at least the next couple gens (Zen 4 this year, 5nm shrink after that); to be seen if that actually wears away Intel's ecosystem advantage much.
Also: software seems like a real advantage for their competitors (CUDA, MKL, ICC). Dunno what the software analogue is of hiring Jim Keller for a few years, but I'd love to see it. Given AMD's position they could benefit from making their GPUs' compute units, and the cores and vector capabilities on their CPUs, usable for mere mortal programmers, as huge an effort as it is.