Is this from the point of view of memory OC'ing? Or just in general terms?
From my own experience, and having done a little looking around, it seems most advise is to steer clear of going above 1.2 on the SOC and in general not to change SOC LLC, leaving it on auto.
I've tricked around with the SOC voltage (mine is at 1.1v). I've reduced it and increased it by 0.05, on standard and offset. It made no difference -my objective was to OC generic 2400 DIMMS to 2733. I got them pretty stable at 1.1 SOC, 1.25v mem, and jedec timings (not XMP or DOCP - it's just to hopeful to dial in lower timings without significantly increasing voltage). So to answer your question, I didn't see any benefit to running SOC offset. For CPU, yes.
I'm not sure if any of that info is relevant or even helpful.