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Maybe it's Autoplay options have gone astray. Right click the optical drive in My Computer, go to Properties and click on the Autoplay tab. Select the option to "Run setup" on any software disk that turns up and tick to do that every time. Blob teh Radio Button to do that every time rather than "Choose an option", click Apply and OK your way out and you might find they work now.
If you ever want to pop in a software disk without it auto-starting, hold down the Shift key while the disk loads and that cancels the operation.