Things like FXAA should not be forced on in the primary 3D settings, that is something that is a game by game choice, and should be set in the specific game profile.
DSR might as well be selected, all it does it give you the option to use it in game. However, smoothness is entirely a personal choice setting. Default is set to 30% I believe, but I've heard some who like 15%, others who like 20% and so on. Experiment.
HBAO+ being forced on is not generally a good idea. That should also be in your personal game profiles. That will prevent you from adjusting the setting in game, and every game I've seen who offers it, has it as a setting in game. You are better off having the choice, rather than having it forced on.
I personally have Adaptive V-sync forced on, but I have a 120hz screen, so going without V-sync at lower FPS does not result in very noticeable tearing. It also prevents any judder/stutter. For the most part, I stick with the defaults and application controlled settings, though DSR is set, as it only gives you more resolution options in games. Power management is one of the other settings you might consider setting to maximum performance if you run into games which aren't fully clocking your GPU, otherwise you can leave it as is.