I've never overclocked any other board, so for me, it seems pretty straight forward: (I'm doing this from memory, so names might be slightly off)
Mash "Delete" button when powering on.
Top selection is what you want. MB Intelligent Tweaker
Second Entry: Advanced CPU Adjustment
Adjust multiplier to highest available (It will tell you, for example my 950 had a x23 multiplier, but my X5690 has a x25)
Move down a bit and adjust the back clock to something reasonable to start (This will control the total CPU frequency. For example: my 950 ran at 173, but my x5690 is set to 180)
Then you need to tune the memory frequency (in the same screen, not the memory settings in the previous menu). Adjust the Memory multiplier to something close to what your memory is set to run at. I have 1333Mhz Corsair memory, But with the 8.0 speed multiplier, I'm running 1440Mhz. If I raise the CPU BCLK, I have to dial the memory down to 6.0 multiplier. Basically, your memory can't go past it's own recommended speed by large amounts.
Lastly, Back up one menu to the Voltage settings. Raise the voltage a bit. For my 950, I ran at 1.37v. But because of the size of my x5690, Even 1.4v caused the CPU to "starve" when running benchmarks. It ran just fine until all cores needed max Freq and then it (didn't crash) just plummeted my FPS. My firestrike on this setup, without the current voltage, would get 14k, with my CPU falling to single digits on the Physics test.
Press F10, and type "Y" to save settings. As soon as it reboots and drops you in Windows, Open CPUz. Windows Task Manager incorrectly reports my computer as 3.37Ghz 4core. So I don't even use it. If CPUz reports stock settings, some part of your OC failed. Maybe Memory Speed, Maybe BCLK multiplier was too high. It will still boot with voltage too low, but your CPU tests will not be where you expect the score.
Ask me anything I didn't cover after using this. Good Choice, and Good Luck.