dylan.m.porter90 :
I want to use the HDD that I've been using for storage as the boot drive for me OS. Will I be able to use a usb to install windows to that drive, also are there any changes that need to be made to the storage/boot settings in the bios if so?
You could use a USB installation media to install Windows 10 on that HDD.
I suggest you disconnect any other drives until you are done installing Windows.
Make sure you backup any data on the HDD you are installing Windows.
Select the custom installation during setup and delete all partitions on the HDD.
Select that drive as the default boot device in the BIOS.
Power off and connect any other drives.