There are a large number of 32-bit games that used older 16-bit installers that also will not work (directly) in a 64-bit environment.
Technically, the games will
run if you can find a way to set them up without going through the installer.
As a general rule, pcgamingwiki.com is a
very good source for finding ways to get specific titles running. I've used it extensively in recent years for figuring out how to get a multitude of my old games running stable.
Aside from that, any title with a DOS executable can/should be run via DOSBOX. That
generally covers most of the Win16 apps that you can't run on 64-bit versions of windows. Everything else typically works with some fiddling; if nothing else Microsoft is good about keeping their legacy APIs stable.
Worst case, you can spin up a VM for either Win98SE or WinME to get those legacy titles running.