Can I run computer from a second drive?

pelfiredc

Honorable
Feb 4, 2013
3
0
10,510
Hello,
I am hoping that this is possible, I have two (supposedly) identical HP Pavillion pcs. On crashed...bad MOBO and the other is fine but the first has programs that I want to run but aren't on second and cant get. I would like to just swap the drives and run the crashed c drive on the working one. When swapped the boot manager window (windows) comes up and says windows failed start.. Hard or soft change ..windows\system32\winload.exe not loaded because missing or corrupt? Status is 0xc000000e not sure what to do or how to rectify!!! Windows ran on the other and were bought as a pair? Any help would be greatly appreciated.