Question Can i run programs from a hard drive with os in another pc?

Feb 16, 2019
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I just build up a gaming pc so i can retire my old one and I don't want to download all my games and programs again, this new PC have already a hard drive with a Os and I want to run the programs by this new hdd os, they are both win 10 and amd based. Is this even possible?
 
Ones that use launchers, such as Steam & Origin, usually can by adding the remote drive to the apps library locations.

Ones that you install, like Office, are usually a No. They write too much data to other portions of the drive, like the hidden AppData folder.