Yes, you can easily run that card. If you are worried about the motherboard having bus type PCI-E 2.0 and the GPU requiring PCI-E 3.0, you don't have to worry about anything. The memory bus of 128 bit on the graphics card run perfectly on PCI-E 2.0. You will not be affected on anything. You would be affected if you wanted to SLI but that motherboard doesn't support SLI so you are good to go.