as long as the motherboard allows it, it's got to be able to handle PCIe 2.0 x 16 to get the correct performance. i3 should be able to handle even an ultra high performance card. It might bottleneck, but i'm pretty positive that it will handle it. That kind of stuff is more reliant on the Motherboard and PSU, with a small consuming CPU like that, a 500W PSU should do it.