No it won't. I have nearly the same dimms in my MSI x370 titanium. Corsair Dominator Platinum 3200mhz 14-16-16-36 @1.35v. Just a different limited edition run. I can get 2 dimms stable at 2933mhz, 4 dimms stable at 2400mhz. This will probably change with continued BIOS updates. The X370 titanium has the hardware to run all 4 dimms at the XMP speeds.