2 things.
Are they in the right slots, if you have 4 slots you'll have two pairs of dual channel, see what your mobo manual says about which slots to use if you only have 2 sticks.
With unbalanced sticks like that either it'll dual 4GB and 4GB (of 8) and leave 4GB (of 8) in single mode, or it'll do all of it as single. As CPU-Z can only report either single or dual, it can't report than some is single and some is dual, then it's difficult to say what's actually going on. However having mixed dual and single channel is not a great idea, windows randomises memory allocation for security reasons, so some memory access events will respond quicker than others.