Some people have done it, but under Windows ATI uses catalyst, and NVIDIA uses NVIDIA control panel, Under Linux they may be able to be configured separately or even a source forge program for windows. Most likely 2 different chipsets support running will have problems. Unless ATI is willing to work with NVIDIA(I.E hydra), its best to just stay with 1 common set GPU chipset. Like hell tech made clear there would have to be a custom bridge for instance a hybrid of CF and SLI not to mention driver support. This post was pretty informative though http://www.tomshardware.com/forum/245454-33-crossfire-faqs