The chipset from Intel will support certain features. It will determine which CPU and Memory is supports, how many SATA ports, how many USB ports, Raid, PCI-E lanes, plus all the fancy stuff such as Intel SRT, SBA, SBB, rapid storage, etc... it will also include features for overclocking on the higher end consumer chipsets.
The big things to look for are PCI-E lanes especially if you use a PCI-E SSD and dual video cards. And Overclocking.
The more features, the more expensive the chipset, and the more expensive the motherboard. So get what you need and pay for what you get. Do not buy more than you need or you waste money, and do not cheap out or you loose features you need. Some gamers cheap out, then realize they can't overclock or use 2 video cards effectively.