RAM purchased separately is never guaranteed to work together, but if it does it will likely need to be run at speed of the slowest stick(s) e.g. 2400 MHz.
I actually don't know what would regarding single vs dual channel if you were to put the 2x4 GB sticks in one channel and the 8 GB stick in the other. It might be dual channel, or maybe it'd run in flex mode (basically part dual channel part single channel).