[SOLVED] Do I need to add stand-offs?

Solution
As folks above said, you need standoffs where they are supposed to be according to your motherboard and case manuals. Usually cases have already installed standoffs for ATX-M boards. And included extra standoff for ATX boards that you must screw in case by yourself. However look into both motherboard and case manuals at first. When board is in case, check if all opened screw holes have standoffs below them (use flashlight if it is too dark).

Motherboard in picture look aligned fine.
Like USAFRet said in your manual it will tell you which standoff needs to be there. After that it's just a question of looking at what standoff are on the case and if it fits the manual you keep them like that. If there is one you need to remove you remove it and if there is missing on you add one. Very easy.
 
As folks above said, you need standoffs where they are supposed to be according to your motherboard and case manuals. Usually cases have already installed standoffs for ATX-M boards. And included extra standoff for ATX boards that you must screw in case by yourself. However look into both motherboard and case manuals at first. When board is in case, check if all opened screw holes have standoffs below them (use flashlight if it is too dark).

Motherboard in picture look aligned fine.
 
Solution