On the X470-F, which is a very decent board, I'd say you stand a good chance of them working especially if you're going to be using the newer Ryzen lineup.
It's not likely to "damage" anything, or else they wouldn't PUT four DIMM slots on there. It's a different kind of stress. It's electrical and thermal stress. I have little concern with being able to get a 4 x8GB kit to run so long as you go with a decent quality set of sticks.
That will, obviously, not be sticks at the low end of the price range. But not necessarily terribly expensive either. DRAM prices are VERY low right now compared to, well, maybe ever, but certainly for years.
A 2 x16GB kit would be preferred though. Not only is it more likely to work out of the box, it's...