Anything is possible. More than likely you'll experience a hang up for that large a file before you'll experience data that's been corrupted in a transfer. If you copy that much data without it hanging on you (which shouldn't happen often in itself), it's not likely it'll be corrupted unless there is something wrong with the hardware.
>>Do you also know if copying all the files from one CD to another is as good as disc-to-disc copy when burning a CD?<<
Do you mean copying to a hard drive first then to a CD. If so, I would say that's always as good or better (but time consuming if you don't have to). For one, the hard disk doesn't need a continuous stream of data to copy the data without errors. Two, more than likely your hard drive's read capabilities are far better than your CD-Rom. I've never had a problem going disc-to-disc with drives in DMA mode.
***check the jumpers 1st then check em again***