Question Dual monitors: mixing different resolutions

[acordeon]

I currently have two 24" 1080p monitors, and am thinking about replacing one with a larger and higher resolution screen, probably a 27" 4k or 1440p. My graphics card should be able to handle it. This is for work, I'm not a gamer. My question is whether having 2 screens of different resolutions next to each other will be weird or distracting, especially if I go 4k.

Anyone tried a combo like this? If so would you recommend it?

 

[Alabalcho]

Can't say anything about 4k, but for many years I had (and still have) setups with one 16:9 and one 4:3 monitors (hand-me-off).