If you run SLI, the cards will act like one, on the other hand if you run multi card without SLI, you can use each card separatelly for a specific task. Running SLI or not really depends on your goal, for gaming you probably want SLI, though some games are not compatible with it. I personally don't use SLI, because my rig is for professional purposes, and the applications I use can take advantage of each card individually. Also if you are in the rendering/editing business (or anything that uses GPU processing), you can use one card just for the monitor(s), and the other card(s) exclusively for your GPU intensive task.