johnmanth :
You can do it (in theory) but is a bad idea cause external hard drives are much more prone to functionality problems, usb is way slower than sata and you can use this hard drive only at one computer(you need a fresh install for each computer)
USB3 is not waaaay slower than SATA ... and you can use ANY drive of ANY quality in USB3 Drive BOX .
The only thing here missing is that Windows does not allow booting from USB3 , but there are ways around it by getting a box with BOTH USB3 AND eSATA connection , and put an external eSATA in the PC and connect it directly to the sata port.