My sons are playing F4 ....
4690K (4.5 Ghz) / Twin 970's @ 18% OC
4770K (4.6 GHz) / Twin 780's @ 26% OC
2600K (4.8GHz) / Twin 560 Ti @ 28% OC
Trying to diagnose problems, the following have been attempted
1. Played as above
2. Played w/ SLI disabled
3. Played w/ GFX cards at stock
4. Payed w/ both CPU and GFX cards at stock
The problem is that they will be sailing along quite nicely and then performance drops to single digit fps. Right now, they've stopped playing in the hope that patches will resolve the problem.
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Wouldn't hold your breath, Skyrim had similar sudden drops.