Turns out this is a known issue:
https://forums.geforce.com/default/topic/621435/geforce-experience/sorry-geforce-experience-cannot-optimize-games-on-this-pc-/3/
In my experiences, GeForce optimization has caused me more issues than manually optimizing settings myself. Though you could try updating your graphics drivers, i'm not convinced this will fix your issue. Hopefully someone else on this forum might know a solution.