update: I removed drivers, removed cards, installed one, installed 12.1 drivers, rebooted 2x, installed 2nd card.
On reboot AMD popped a message indicating I was in Crossfire. CCC briefly went into a mode where I could NOT disable it - had a grayed out CrossfireX tab, showing 2 GPUs.
I see a "Linked Card" in CCC which to my mind means that CrossFire is working. But I don't see a CCC menu consistent with documentation - I can't configure the GPUs.
I tried Skyrim and it was passable, but deteriorated to about 0.5 FPS after about 10 minutes of play (yes, a frame every two seconds). Enabled AMD Overdrive and it returned to the cryptic behavior: "Choose to enable AMD CrossFireX..." with a grayed out Apply button.
I can choose to Disable it and then I can Apply. When I do that, the second adapter shows as Disabled.
Probably going to go to the 12.2 drivers next, but they have known issues with Skyrim.
Note: I am attempting to play Skyrim across three monitors, 5760 x 1200. Amazed at how challenging this has been, with all new hardware.
Edited yet again: OK, I ran Furmark. Both GPUs were clearly under load, got the temp quickly up to 75c. So it's a Skyrim issue. But not helped by puzzling AMD user interface, inconsistent w/docs.
MSI X79A-GD45 | SilverStone 1200w Strider Gold | Intel i7-3820 @ 3.6 (stock) |16 gB Patriot 1.5v DDR3 (1333 or 1600, researching) | 2x Sapphire HD 6850 | 3x 24" Dell Ultrasharps