If it's a SATA M.2 SSD (like the 850 EVO M.2) then yes, it will just work no problems. If it's an NVMe SSD (like the 950 Pro) then you need to make sure you have the latest BIOS for your motherboard. According to the Asus Website the X99 Sabertooth does support booting from an NVMe with certain (later) BIOS versions.