Running mismatched ram in the past I put the slower ram in the primary ram slots, channel 1, slot a, channel 2, slot a and I put the faster ram in slots b.
I was able to run xmp and it was stable with the faster ram dialled back to the slower speeds.
You really are better off buying 2x 16GB sticks and putting the memory you already have to one side.
Even matched memory can have problems working with 4 sticks, there are always tolerances.