It's related to the OC, but the OC isnt the cause, but a victim. It's most likely the game itself.
Different engines use different programming and for the 99% most part, you'll have 0 issues with OC stability. But just like ppl who advise running a stress test overnight, it's that 1% that never happens, that finally does.
No OC is 100% stable, as soon as you change any single parameter, you are at 99% at best.
And some programs just have a better chance at finding that 1% anomoly and causing a crash.
To get around that you'd need to change things in your OC, add a few more mV, change c-states, change ram timings, something will work, it's just a matter of finding it. Although you may not be happy with the results.