Very delicately! Make sure your wearing a anti-static wrist strap attached to the case or a grounded metal object. The less your able to handle it the better.How to hold a motherboard?
just watch jay hereHow to hold a motherboard?
Which part of it is safe to be hold?
Linus drops everythingprimarily ppl hold em by the bottom and side. (where none of the parts that can easily break off are)
and after you have CPU heatink tightened down by that (since its basically most secure and stable part at that point if tightened properly)
They arent THAT fragile (Linus from LTT has even dropped em and still worked but i dotn advise doing that) and as long as your not wearing socks on carpet or some clothign that knowingly generates static you'll be fine.
some cases lack room to hold sides and put into place so heatsink lets you have a firm place to grip in those situations. (not ideal, but basically safe when required)Never had to touch them anywhere except the edges... can’t fathom trying to hold on by the heatsink or another part.