Intel's Alder Lake brings disruptive new architectures and reportedly supports features like PCIe 5.0 and DDR5 that leapfrog AMD and Apple in connectivity technology, but the new chips come with significant risks.
I wouldn't really say PCIe 5 and DDR5 are "leapfrogging" AMD. There might be some Alder Lake notebooks on the market before the end of the year, but it seems less likely that Alder Lake desktop chips will be available until early next year. AMD will likely have their own new DDR5 platform launching around the same time, or not long thereafter.
And considering even PCIe 4 doesn't really provide any tangible benefits to desktop PCs at this time, outside of certain specialized usage scenarios, PCIe 5 might be limited to server platforms. On desktops, it would likely just make motherboards more expensive to manufacture while not offering much in return. And again, even if Intel did support it on their mainstream platforms, AMD might as well.
As for the "BigLittle" architecture, it's probably more beneficial to notebooks, where running things on the Atom cores could result in longer battery run-times, while still offering better performance when needed. From a performance perspective, I wouldn't expect it to do too much on desktop systems, but if desktop computers drew less power at idle by shutting down the performance cores, that could save power, and over the course of a few years, those efficiency cores might pay for themselves. They might also assist at improving performance in certain heavily-multithreaded tasks, though whether it would be more beneficial to dedicate that silicon to additional performance cores remains to be seen.
The listed product lineup seems like a mess though, at least if they don't narrow it down for consumer-facing parts. Determining how many small cores might be beneficial to someone could be a bit vague, as well as whether they might be better served by a processor with more big cores instead.