Cyberat_88 :
The future is e-sata III thumb drives.
With USB3.1 just around the corner and UASP, as kludgy as that may sound, I doubt there would be that much demand for e-SATA3 since USB3.1/UASP would be both faster and more portable.
If you really want to eliminate piling up protocols and getting the most speed possible, native PCIe storage, internal or over Thunderbolt which practically is e-PCIe, would be the ideal thing.