if both r of the same speed and timings, the 2 4gb should be in the same color ram slots and so should be the 8gb sticks. then u will have 12gb of rams in dual channel mode. if the rams r @ different speeds n timings, if u have a z series mobo, u can try custom timings to match them. if they match n they r stable, u r good to go. otherwise, u have to stick with the mobo default timings and deal with the reduced perf. simply put, avoid the hassle.