1. Buy RAM appropriate for your board
a. On a dual channel board, always by RAM in packages of 2 minimum, if you want more, buy 4 in same package
b. On a quad channel board, always by RAM in packages of 4 minimum, if you want more, buy 8 in same package
b. On a triple channel board, always by RAM in packages of 3 minimum, if you want more, buy 8 6n same package
2. Mixing RAM from separate packages is always a crap shoot, may work , may not but you have no guarantee is it doesn't. It very may be that the single RAM stick you buy may have been sold in a single package because it failed in in-house testing when paired with another stick.
3. You have more to worry about than speed, what about timings and voltages ? You will have...