I'd say no for this reason. Your second pci e slot. (the one where you'd be installing the second card to) is in fact a pci x16 slot. However it runs in x4 mode. Which means only 4 lanes. So the performance would be crippled. By how much? I'm not sure. But that's the reason I didn't crossfire my own setup. If you really want to you can try it, I'm just not sure if it'd be performing as well because of the x4 slot.