Ok, well that's another thing eliminated. I forgot to ask, and it isn't in your listed specs, is your system drive an SSD or HDD? Do you have secondary drives etc. A system wide stutter even on the desktop is likely not the GPU, but could be caused by a slow or failing drive. If you haven't done so already, it might be worthwhile disconnecting any secondary hardware and peripherals. I've seen some odd things before. Had a mouse cause perceived in game stutter because of a bad connection internally. Anyways, take the system down to basics. CPU, GPU, a single stick of RAM and nothing else. Just enough to run. IF the stutter has gone, add things back one by one. If it hasn't gone, it's either a BIOS setting (setup defaults aren't always the best, especially with X3D processors), or a possible hardware issue. Also, re-seat everything, ensure the motherboard is grounded properly to the case either through the IO shield or the stand offs. I'm just throwing s*** at the walls here so if you've tried some of this already take no offense. Also, monitor EVERYTHING. Watch CPU clockspeed, temperature, core activity. Same with GPU. Take note of any abnormalities. Keep an eye on RAM and VRAM utilization. All of this can be done with Afterburner, Ryzen master, HWInfo or the like. Stutter like this can be VERY difficult to nail down.