Do you think anyone but the government would throw away a multimillion dollar CNC machine just because there are no Windows 2000 or later drivers for it? 100 year old machine tools are common and even if a newer machine works better/faster, the old one is not only paid for but it would require paying to dismantle it much like demolishing a house--it's not free to get rid of it.
NT4 is surprisingly compatible and here it is running on Ryzen 9
however I suspect most users are still trying to nurse along their ISA-slot equipped vintage PCs.
I don't see a problem if it's not on an internet-connected network or at least segmented from it. It has been increasingly difficult to connect to it from later OSes and now
Microsoft has stripped NTLMv1 and the DES it uses from Windows 11 24H2 and Windows Server 2025, so NTLMv2 introduced in SP4 is it unless you want to use a 3rd party Kerberos client. Needless to say, you have to open up so many security holes to get this to work that the modern PC shouldn't be internet-connected either.