Mismatched RAM like that will always be questionable.I have a H110M-R and it freezes and crashes in 1 slot but works fine in the other. My rams are ok and so is everything. Heres the picture and the full pc specs :
CPU : E3 1270 V6
GPU : RX 570
MOBO : H110M-R
PSU : FSP600-80PSA (6 months old)
RAM : Cruicial 4gb + Samsung 8 gb