It depends. Using x86, c++ etc, do you think that helps LRB?
If the app is designed for it, definately, and having their feet in the water long before LRB, making a few inroads here and there , they gain more traction, and the longer LRB takes, the more wins Fermi gets.
As for HPC, it may be too late anyways for LRB, but again, its too early