All depends on how it's done. If you case mod a Sata connection, there'll be no loss as the sshd will still be a Sata-Sata connection. It'll just be sitting outside of the case vrs sitting inside. If you convert to USB3, then you might get some loss as it'll depend on the traffic your USB is using in the laptop. If forced to use USB2, then you will get loss, but it'll be a conditional thing as the sshd is going to be a storage drive, not the OS drive, and programs/files will be loaded through the sshd cache initially, writing/reading as needed or when time permits, so after initial load, you'll basically still be running ssd speeds from the sshd, but waiting on transmission speeds via USB. With small/normal files, it shouldn't be an...