It's easy enough, the CPU will have 0 effect on the change, all you really have to do is uninstall all the drivers from your current motherboard (sound, network, chipset, etc), shut down and then make the change. Make sure to leave everything at stock the first time you're going to boot the new build (just set boot priority for drives), install all necessary new drivers for the board in Windows, and once you've made sure everything's up and running as it should, you can get started on changing things in BIOS (overclock, etc).
I've personally moved from a z68 setup to a z97 one on the same install and I've had 0 problems.