You can use a M.2 if the mobo has a M.2 slot. If the BIOS supports NVME you maybe or should be able to use that
This mobo has one but since there's only 4 sata ports, if I decided to install a M.2 ssd, it'll disable 2 of my sata ports
Altho there's not much in it anyway, there's only 1 250 GB ssd and a dvd writer.
I dont know why I've got the dvd, I've never really used it since I installed it lol