I would make the bottom 3 fans Intake fans pulling in cold air from the bottom of the case no matter what you end up doing. That's a guarantee to be the best in any scenario IMO. Hot air rises. Air is colder near the floor.
I would probably do one of the following. (You can also try them and see what your thermals are and pick what's better, fans are pretty easy to switch around. Moving the AIO is not though)
1-CPU temp priority. Set the single back fan as an exhaust, the top 3 as exhaust, and have the AIO on the side/back panel as an intake. This prioritizes cooling the CPU. You set the AIO to intake so it pulls in cool air and keeps your CPU as cool as possible. The tradeoff is that it will introduce hot air into the rest of the build as well as it blows out the radiator into your case. But since you have so many intake fans in this scenario, the fact the AIO is off to the side not right over your motherboard/GPU, and a good airflow pattern from bottom to top, it might be a good balance of thermals across the entire build.
2-GPU temp priority. If CPU temps are not a problem for you at all and you would rather sacrifice some CPU thermals for keeping other parts cooler, you can also set it up in this configuration. AIO at the top running as an exhaust, back fan running as an exhaust, and the bottom and side panels as intakes. This brings in 6 fans worth of cool air all being pulled from the bottom and side and up the top and back of the PC case and out. This will 100% be hotter for your CPU than option 1 but will likely give you better GPU thermals. If your CPU is giving good thermals here, this would be the ideal scenario IMO. As it would keep your overall system and GPU the coolest.
3-Least Ideal IMO. Third option is running the AIO as an exhaust on the side of the case. But in that situation, you will only have the 3 intake fans at the bottom, and then exhausts at the back, top, and side(AIO) of your build with more exhausts than intakes. I am not sure this will be a good pressure/airflow. And since the AIO is an exhaust in this situation your CPU is going to run warmer than if it was an intake anyway. You could make the back fan an intake for a total of 4 intake fans, but that air is just going to be sucked out the top immediately and do nothing for your components. You could reverse the entire setup and pull cold air from the top and exhaust out the bottom, but hot air rises. IMO this would be the least ideal.
I would start with 2 personally, and see where I am at. Depending on the GPU/CPU temps I might switch to 1 if the CPU absolutely needed to be cooled down more, and the GPU could handle a few more degrees.
Edit- I also should add, this depends on what you are gaming on. I play in 4k, so my CPU barely breaks a sweat. The GPU is doing all the heavy lifting, so I have to prioritize GPU cooling.
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